Dr Abdelrahman Mayhoub

 

  1.  Eid, I. et al. Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. European Journal of Medicinal Chemistry 139, 665-673, doi:10.1016/j.ejmech.2017.08.039 (2017).
  2.          Eissa, I. H. et al. Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. European Journal of Medicinal Chemistry 130, 73-85, doi:10.1016/j.ejmech.2017.02.044 (2017).
  3.          ElAwamy, M. et al. Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens. European Journal of Medicinal Chemistry 152, 318-328, doi:10.1016/j.ejmech.2018.04.049 (2018).
  4.          Eldesouky, H. E., Mayhoub, A., Hazbun, T. R. & Seleema, M. N. Reversal of azole resistance in Candida albicans by sulfa antibacterial drugs. Antimicrobial Agents and Chemotherapy 62, doi:10.1128/AAC.00701-17 (2018).
  5.          Elsebaei, M. M. et al. Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA). European Journal of Medicinal Chemistry 148, 195-209, doi:10.1016/j.ejmech.2018.02.031 (2018).
  6.          Hagras, M. et al. Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity. ACS Infectious Diseases, doi:10.1021/acsinfecdis.8b00172 (2018).
  7.          Hagras, M. et al. Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. European Journal of Medicinal Chemistry 143, 1448-1456, doi:10.1016/j.ejmech.2017.10.048 (2018).
  8.          Hagras, M. et al. Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA). Journal of Medicinal Chemistry 60, 4074-4085, doi:10.1021/acs.jmedchem.7b00392 (2017).
  9.          Kotb, A. et al. Tert -Butylphenylthiazoles with an oxadiazole linker: A novel orally bioavailable class of antibiotics exhibiting antibiofilm activity. RSC Advances 9, 6770-6778, doi:10.1039/c8ra10525a (2019).
  10.          Kotb, A. et al. Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. European Journal of Medicinal Chemistry 151, 110-120, doi:10.1016/j.ejmech.2018.03.044 (2018).
  11.          Mohammad, H. et al. Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. Journal of Medicinal Chemistry 60, 2425-2438, doi:10.1021/acs.jmedchem.6b01780 (2017).
  12.          Mohammad, H. et al. Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus. PLoS ONE 12, doi:10.1371/journal.pone.0182821 (2017).
  13.          Yahia, E. et al. Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. European Journal of Medicinal Chemistry 126, 604-613, doi:10.1016/j.ejmech.2016.11.042 (2017).