Reem Arafa

academic title

Professor of Biomedical Sciences

Position

Director of the Drug Design and Discovery lab

Contact Information

Email: rkhidr@zewailcity.edu.eg

 

 

About

Education: Doctor of Philosophy degree in Applied Organic Chemistry from Georgia State University, U.S.

Research Areas: Computer-aided drug design, molecular modeling, medicinal chemistry, drug discovery.

Research Interests: Design, synthesis and biological evaluation of small molecules with diagnostic and therapeutic capacity. Using computer-aided molecular modeling techniques to understand the behavior of molecular targets upon binding interactions with ligands.

Keywords: Drug design, molecular modeling, medicinal chemistry, small molecules, diagnostics, therapeutics.

 

 

Researcher Links

Scopus, Google, Scholar

 

Recent Publications

1) NE Abo-elmagd, RF George, MA Ezzat, RK Arafa - New 1-phthalazinone Scaffold based Compounds: Design, Synthesis, Cytotoxicity and Protein Kinase Inhibition Activity, Minirev. Med. Chem., 2018, 18,1759-1774.
 
2) NK Sedky, ZH El Gammal, AE Wahba, E Mosad, ZY Waly, AA El‐Fallal, RK Arafa, N El‐Badri, The molecular basis of cytotoxicity of α‐spinasterol from Ganoderma resinaceum: Induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines, J. Cell. Biochem., 2018, 119, 3892-3902
 
3) H Mohammad, NH Elghazawy, HE Eldesouky, YA Hegazy, W Younis, L Avrimova, T Hazbun, RK Arafa, MN Seleem, Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis, ACS Infect. Dis., 2018, 4, 403-414.
 
 

Grants

1) Title: Design and Synthesis of BET Inhibitors as Anticancer Agents. Project No. 5, Egypt -France Scientific and Technological Cooperation Program “IMHOTEP”, Cairo, Egypt.

2) Title: Alzheimer’s disease: design, synthesis and biological efficacy screening of new potential therapeutic entities for an old disease, Project No. ASRT 4, Jesor, Cairo, Egypt.

3) Title: Structural studies on Riboswitches as potential drug targets, Project No. ASRT 14, Jesor, Cairo, Egypt.

 

Research Highlights

1) 2015 Egyptian State  Incentive Award for Advanced Technological Sciences Award in Medical Sciences