New publication on Point-of-Care Diagnostics of COVID-19


Dr. Rabeay Younes, Associate Professor of Nanoscience at Zewail City, has recently published a new article titled “Point-of-Care Diagnostics of COVID-19: From Current Work to Future Perspectives” in the journal of Sensors. Coronaviruses have received global concern since 2003 when an outbreak caused by SARS-CoV emerged in China. Later on, in 2012, the Middle-East respiratory syndrome spread in Saudi Arabia, caused by MERS-CoV. Currently, the global crisis is caused by the pandemic SARS-CoV-2, which belongs to the same lineage of SARS-CoV. In response to the urgent need of diagnostic tools, several lab-based and biosensing techniques have been proposed so far. The diagnostics developed starting from cell-culture detection and the microneutralization using pseudovirus particles to have a privilege of BSL2. The genetic featuring for the virus detection in nasopharyngeal swabs using Real-time polymerase chain reaction (RT-PCR). On the other side, immunoassays were developed, either by screening/antigen recognition of IgM/IgG or by detecting the whole virus, in blood and sera. Finally, for lower than 10 minutes of virus detection by using virus-biosensing techniques electrochemically and eye-based technologies in swab specimens. Alternatively to swab-based techniques, lateral flow point-of-care immunoassays are already commercially available for the analysis of blood samples. Such biosensing devices hold the advantage of being portable for on-site testing in hospitals, airports, and hotspots, virtually without any sample treatment or complicated lab precautions.