Sherif El-Khamisy's Publications




1Walker, C. & El-Khamisy, S. F. Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. Brain 141, 1247-1262, doi:10.1093/brain/awy076 (2018).

2Shawky, S. M., Awad, A. M., Abugable, A. A. & El-Khamisy, S. F. Gold nanoparticles – An optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. International Journal of Nanomedicine 13, 8137-8151, doi:10.2147/IJN.S181732 (2018).

3Samir, N. et al. Competing endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. Journal of Cellular Biochemistry 119, 6869-6881, doi:10.1002/jcb.26884 (2018).

4Mohamed, Z. et al. miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. Oncotarget 9, 30053-30065, doi:10.18632/oncotarget.25698 (2018).

5Liao, C. et al. UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. Cell Reports 23, 3352-3365, doi:10.1016/j.celrep.2018.05.033 (2018).

6Hegazy, M. T. et al. Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. EBioMedicine 35, 106-113, doi:10.1016/j.ebiom.2018.08.007 (2018).

7Fleifel, D. et al. Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's. Journal of Genetic Engineering and Biotechnology 16, 427-432, doi:10.1016/j.jgeb.2018.09.002 (2018).

8Elserafy, M. & El-Khamisy, S. F. Choose your yeast strain carefully: The RAD5 gene matters. Nature Reviews Molecular Cell Biology 19, 343-344, doi:10.1038/s41580-018-0005-2 (2018).

9Elserafy, M., Abugable, A. A., Atteya, R. & El-Khamisy, S. F. Rad5, HLTF, and SHPRH: A Fresh View of an Old Story. Trends in Genetics 34, 574-577, doi:10.1016/j.tig.2018.04.006 (2018).

10Walker, C. et al. C9orf72 expansion disrupts ATM-mediated chromosomal break repair. Nature Neuroscience 20, 1225-1235, doi:10.1038/nn.4604 (2017).

11Shawky, S. M., Awad, A. M., Allam, W., Alkordi, M. H. & El-Khamisy, S. F. Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. Biosensors and Bioelectronics 92, 349-356, doi:10.1016/j.bios.2016.11.001 (2017).

12Lissek, T. et al. Building Bridges through Science. Neuron 96, 730-735, doi:10.1016/j.neuron.2017.09.028 (2017).

13Chiang, S. C. et al. Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage. Science Advances 3, doi:10.1126/sciadv.1602506 (2017).

14Atteya, R., Ashour, M. E., Ibrahim, E. E., Farag, M. A. & El-Khamisy, S. F. Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. Mechanisms of Ageing and Development 161, 141-148, doi:10.1016/j.mad.2016.04.012 (2017).

15Allam, W. R., Ashour, M. E., Waly, A. A. & El-Khamisy, S. in Advances in Experimental Medicine and Biology Vol. 1007   41-58 (2017).

16Abugable, A. A. et al. in Advances in Experimental Medicine and Biology Vol. 1007   157-178 (2017).

17Elsayed, W., El-Shafie, L., Hassan, M. K., Farag, M. A. & El-Khamisy, S. F. Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. Scientific reports 6, 26626, doi:10.1038/srep26626 (2016).

18Meisenberg, C. et al. Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Molecular Cancer Therapeutics 14, 575-585, doi:10.1158/1535-7163.MCT-14-0762 (2015).

19Hassan, M. K. et al. P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane. Oncoscience 2, 294-308, doi:10.18632/oncoscience.143 (2015).

20Carroll, J. et al. Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics 24, 828-840, doi:10.1093/hmg/ddu500 (2015).

21Ashour, M. E., El-Shafie, L. & El-Khamisy, S. F. in Cancer Metastasis - Biology and Treatment Vol. 20   39-74 (2015).

22Ashour, M. E., Atteya, R. & El-Khamisy, S. F. Topoisomerase-mediated chromosomal break repair: An emerging player in many games. Nature Reviews Cancer 15, 137-151, doi:10.1038/nrc3892 (2015).

23Wells, O. S. & El-Khamisy, S. F. in Movement Disorders: Genetics and Models: Second Edition     1033-1041 (2014).

24Meisenberg, C., Ward, S. E., Schmid, P. & El-Khamisy, S. F. TDP1/TOP1 ratio as a promising indicator for the response of small cell lung cancer to topotecan. Journal of Cancer Science and Therapy 6, 258-267, doi:10.4172/1948-5956.1000280 (2014).

25Gómez-Herreros, F. et al. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics 46, 516-521, doi:10.1038/ng.2929 (2014).

26Alagoz, M., Wells, O. S. & El-Khamisy, S. F. TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research 42, 3089-3103, doi:10.1093/nar/gkt1260 (2014).

27Alagoz, M., Chiang, S. C., Sharma, A. & El-Khamisy, S. F. ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells. PLoS ONE 8, doi:10.1371/journal.pone.0058239 (2013).