Zewail City Researchers Identify a Promising Bacteriophage-based Treatment for Multidrug-resistant Klebsiella Pneumonia

Multi-drug-resistant Klebsiella pneumoniae (MDR-KP) has steadily grown beyond antibiotic control. Wound infection kills many patients each year, due to the entry of multidrug-resistant (MDR) bacterial pathogens into the skin gaps. 

A research group led by Dr. Ayman El-Shibiny, Director of Zewail City's Center for Microbiology and Phage Therapy (CMP), succeeded in using bacteriophage ZCKP8 to control clinical isolate KP/15. The therapeutic efficiency of phage suspension and a phage-impeded gel vehicle were assessed in vivo against a K. pneumoniae infected wound on a rat model and the results showed the highest healing efficiency by lowering the infection. Phage ZCKP8 showed excellent potential to be used as a therapeutic agent against K. pneumoniae infections. 

The research titled “Topically Applied Bacteriophage to Control Multi-Drug Resistant Klebsiella pneumoniae Infected Wound in a Rat Model” was published in Antibiotics.